Our lab takes a systems and genome biology approach to the study of living organisms. We combine computational and experimental biology including bioinformatics, modeling, deep sequencing, genome engineering and synthetic biology.
We study the structure, function and evolution of gene expression regulatory networks. Our emphasis is on the phase of protein translation. We are interested in the various factors that govern the efficiency of the process including the interplay between the tRNA pool in the cell and the translated mRNAs. We decipher regulatory networks that couple between transcription and translation of genes and transcription of tRNA genes.
A prime interest is molecular and genome evolution. We study mechanisms of evolution that acts as optimization engines. We evolve yeast and bacteria in the lab with a dedicated robotic system and study the relationships between the environment and the changing sequence and structure of the genome. We are searching for genes and cellular mechanisms that endow organisms with the ability to evolve. In parallel we investigate the cancerous genome as it evolves.